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). In its hazard assessments for methylene chloride and NMP, EPA recognized threats to youngsters from publicity to methylene chloride and NMP Employed in paint and coating removal. EPA has also recognized Women of all ages of childbearing age as being a most likely uncovered or vulnerable subpopulation who may be at bigger possibility than the general inhabitants of adverse wellbeing consequences from exposure to NMP. EPA has recognized this subpopulation as appropriate to EPA's possibility evaluation for NMP on account of NMP's results to the developing fetus. As a result, the chance management normal underneath Section six of TSCA, with respect to NMP, should be to decrease the risk posed by NMP so that it not provides an unreasonable hazard (both to buyers in the general population or to customers who will be Women of all ages of childbearing age).
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Methylene chloride is mainly released to the ecosystem in air, also to a lesser extent in water and soil, because of industrial and shopper makes use of as being a solvent, in aerosol merchandise, and in paint and coating removal. A lot of chemical waste web-sites consist of methylene chloride and these could possibly work as extra sources of environmental contamination by means of spills, leaks, or evaporation.
These conclusions are dependant on the weight-of-evidence analysis that EPA done in the obtainable literature to the efficacy of labeling and warnings. This analysis signifies that a label's performance at modifying person actions to comply with Guidance and warnings relies on the attributes on the label and the person, And just how those interact for the duration of multiple human details processing phases, such as consideration, comprehension, judgement, and motion (Ref. 28).
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The evaluation determined the subsequent threats from acute exposures to methylene chloride when Utilized in paint and coating elimination (Ref. 2):
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Non-cancer outcomes of chronic exposure to methylene chloride are primarily hepatic; the liver is easily the most sensitive focus on for non-cancer toxicity. Life span exposure in rats dosed with distinct concentrations is connected to hepatic vacuolation, degeneration, or liver necrosis.
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EPA is usually proposing to involve that any paint or coating removing goods that contains methylene chloride that proceed to become dispersed be packaged in containers by using a volume no under fifty five gallons, apart from formulations especially manufactured for that Division of Defense, which can be distributed in containers with volumes no a lot less than 5 gallons.
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